| Date | Home | Away | Result |
|---|---|---|---|
| 8/5/22 1:45 PM | Club Brugge | SV Zulte-Waregem | 1-1 |
| 8/6/22 9:00 AM | KRC Genk | KAS Eupen | 4-2 |
| 8/6/22 11:15 AM | KV Kortrijk | Sint-Truidense VV | 0-0 |
| 8/6/22 11:15 AM | Sporting Charleroi | KV Oostende | 1-3 |
| 8/6/22 1:45 PM | KV Mechelen | Royale Union Saint-Gilloise | 3-0 |
| 8/7/22 6:30 AM | Standard Liège | KSV Cercle Brügge | 2-0 |
| 8/7/22 9:00 AM | KAA Gent | KVC Westerlo | 2-1 |
| 8/7/22 11:30 AM | RSC Anderlecht | RFC Seraing | 3-1 |
| 8/7/22 2:00 PM | Royal Antwerp FC | OH Leuven | 4-2 |