| Date | Home | Away | Result |
|---|---|---|---|
| 12/26/21 6:30 AM | KSV Cercle Brügge | Club Brugge | 2-0 |
| 12/26/21 9:00 AM | Standard Liège | SV Zulte-Waregem | 0-1 |
| 12/26/21 11:30 AM | Royale Union Saint-Gilloise | KAA Gent | 0-0 |
| 12/26/21 2:00 PM | KV Oostende | KRC Genk | 0-4 |
| 12/27/21 11:45 AM | KV Mechelen | RFC Seraing | 2-0 |
| 12/27/21 11:45 AM | Sporting Charleroi | OH Leuven | 0-3 |
| 12/27/21 2:00 PM | K. Beerschot V.A. | RSC Anderlecht | 0-7 |
| 12/27/21 2:00 PM | Sint-Truidense VV | KAS Eupen | 2-0 |
| 2/2/22 11:45 AM | KV Kortrijk | Royal Antwerp FC | 0-2 |