| Date | Home | Away | Result |
|---|---|---|---|
| 7/29/22 1:45 PM | Royale Union Saint-Gilloise | Sporting Charleroi | 1-0 |
| 7/30/22 9:00 AM | KSV Cercle Brügge | RSC Anderlecht | 1-0 |
| 7/30/22 11:15 AM | OH Leuven | KVC Westerlo | 2-0 |
| 7/30/22 11:15 AM | KV Oostende | KV Mechelen | 2-1 |
| 7/30/22 1:45 PM | KAA Gent | Sint-Truidense VV | 1-1 |
| 7/31/22 6:30 AM | KRC Genk | Standard Liège | 3-1 |
| 7/31/22 9:00 AM | KAS Eupen | Club Brugge | 2-1 |
| 7/31/22 11:30 AM | RFC Seraing | KV Kortrijk | 0-1 |
| 7/31/22 2:00 PM | Royal Antwerp FC | SV Zulte-Waregem | 1-0 |