| Date | Home | Away | Result |
|---|---|---|---|
| 12/23/22 11:30 AM | RFC Seraing | KAS Eupen | 0-1 |
| 12/23/22 1:30 PM | KAA Gent | Standard Liège | 0-0 |
| 12/23/22 1:30 PM | KV Mechelen | KSV Cercle Brügge | 1-1 |
| 12/26/22 6:30 AM | Club Brugge | OH Leuven | 1-1 |
| 12/26/22 9:00 AM | Royale Union Saint-Gilloise | KV Oostende | 3-0 |
| 12/26/22 11:15 AM | KV Kortrijk | KRC Genk | 1-0 |
| 12/26/22 1:45 PM | Sporting Charleroi | RSC Anderlecht | 0-1 |
| 12/27/22 1:00 PM | Sint-Truidense VV | SV Zulte-Waregem | 2-0 |
| 12/27/22 1:00 PM | KVC Westerlo | Royal Antwerp FC | 3-3 |