| Date | Home | Away | Result |
|---|---|---|---|
| 10/21/22 1:45 PM | KSV Cercle Brügge | Sporting Charleroi | 4-1 |
| 10/22/22 9:00 AM | KV Kortrijk | KVC Westerlo | 0-2 |
| 10/22/22 11:15 AM | KV Mechelen | KAS Eupen | 2-1 |
| 10/22/22 11:15 AM | Sint-Truidense VV | OH Leuven | 0-0 |
| 10/22/22 1:45 PM | Royale Union Saint-Gilloise | Club Brugge | 2-2 |
| 10/23/22 6:30 AM | Royal Antwerp FC | KRC Genk | 1-3 |
| 10/23/22 9:00 AM | KAA Gent | RFC Seraing | 2-1 |
| 10/23/22 11:30 AM | Standard Liège | RSC Anderlecht | 3-1 |
| 10/23/22 2:00 PM | KV Oostende | SV Zulte-Waregem | 2-1 |