| Date | Home | Away | Result |
|---|---|---|---|
| 10/18/22 11:30 AM | KAS Eupen | OH Leuven | 4-2 |
| 10/18/22 11:30 AM | Sporting Charleroi | KV Kortrijk | 2-2 |
| 10/18/22 1:45 PM | KRC Genk | KVC Westerlo | 6-1 |
| 10/18/22 1:45 PM | RFC Seraing | KSV Cercle Brügge | 0-1 |
| 10/19/22 11:30 AM | Royale Union Saint-Gilloise | KAA Gent | 2-0 |
| 10/19/22 1:45 PM | Club Brugge | Sint-Truidense VV | 3-0 |
| 10/19/22 1:45 PM | KV Mechelen | Standard Liège | 2-0 |
| 10/20/22 11:30 AM | Royal Antwerp FC | KV Oostende | 3-0 |
| 10/20/22 1:45 PM | SV Zulte-Waregem | RSC Anderlecht | 3-2 |