| Date | Home | Away | Result |
|---|---|---|---|
| 10/31/25 2:45 PM | Standard Liège | Sporting Charleroi | 3-1 |
| 11/1/25 10:00 AM | SV Zulte-Waregem | Royale Union Saint-Gilloise | 1-4 |
| 11/1/25 12:15 PM | Club Brugge | FCV Dender EH | 2-1 |
| 11/1/25 2:45 PM | RSC Anderlecht | KV Mechelen | 3-1 |
| 11/2/25 6:30 AM | KVC Westerlo | KRC Genk | 0-1 |
| 11/2/25 9:00 AM | OH Leuven | KAA Gent | 4-0 |
| 11/2/25 11:30 AM | Sint-Truidense VV | Royal Antwerp FC | 1-0 |
| 11/2/25 12:15 PM | RAAL La Louviere | KSV Cercle Brügge | 2-1 |