| Date | Home | Away | Result |
|---|---|---|---|
| 10/14/22 1:45 PM | KVC Westerlo | RFC Seraing | 2-2 |
| 10/15/22 9:00 AM | KV Kortrijk | SV Zulte-Waregem | 1-3 |
| 10/15/22 11:15 AM | KSV Cercle Brügge | KAS Eupen | 5-1 |
| 10/15/22 11:15 AM | Sint-Truidense VV | Sporting Charleroi | 2-1 |
| 10/15/22 1:45 PM | OH Leuven | KRC Genk | 0-1 |
| 10/16/22 6:30 AM | Standard Liège | Royal Antwerp FC | 3-0 |
| 10/16/22 9:00 AM | KAA Gent | KV Mechelen | 3-0 |
| 10/16/22 11:30 AM | RSC Anderlecht | Club Brugge | 0-1 |
| 10/16/22 2:00 PM | KV Oostende | Royale Union Saint-Gilloise | 1-6 |