| Date | Home | Away | Result |
|---|---|---|---|
| 9/30/22 1:45 PM | Standard Liège | RFC Seraing | 0-2 |
| 10/1/22 9:00 AM | OH Leuven | Royale Union Saint-Gilloise | 0-3 |
| 10/1/22 11:15 AM | KV Oostende | KRC Genk | 1-2 |
| 10/1/22 11:15 AM | KVC Westerlo | SV Zulte-Waregem | 2-0 |
| 10/1/22 1:45 PM | Club Brugge | KV Mechelen | 3-0 |
| 10/2/22 6:30 AM | RSC Anderlecht | Sporting Charleroi | 0-1 |
| 10/2/22 9:00 AM | KAA Gent | KSV Cercle Brügge | 3-4 |
| 10/2/22 11:30 AM | KV Kortrijk | Royal Antwerp FC | 2-1 |
| 10/2/22 2:00 PM | Sint-Truidense VV | KAS Eupen | 0-1 |