| Date | Home | Away | Result |
|---|---|---|---|
| 9/9/22 1:45 PM | Sint-Truidense VV | Standard Liège | 1-2 |
| 9/10/22 9:00 AM | KV Kortrijk | KV Mechelen | 1-4 |
| 9/10/22 11:15 AM | KV Oostende | KAS Eupen | 1-0 |
| 9/10/22 11:15 AM | RFC Seraing | Club Brugge | 0-2 |
| 9/10/22 1:45 PM | OH Leuven | Sporting Charleroi | 3-2 |
| 9/11/22 6:30 AM | KVC Westerlo | RSC Anderlecht | 2-1 |
| 9/11/22 9:00 AM | KSV Cercle Brügge | Royal Antwerp FC | 0-2 |
| 9/11/22 11:30 AM | Royale Union Saint-Gilloise | KRC Genk | 1-2 |
| 9/11/22 2:00 PM | KAA Gent | SV Zulte-Waregem | 2-0 |