| Date | Home | Away | Result |
|---|---|---|---|
| 8/26/22 1:45 PM | Sporting Charleroi | Club Brugge | 1-3 |
| 8/27/22 9:00 AM | RFC Seraing | KRC Genk | 0-4 |
| 8/27/22 11:15 AM | KSV Cercle Brügge | SV Zulte-Waregem | 1-1 |
| 8/27/22 11:15 AM | OH Leuven | KV Oostende | 2-1 |
| 8/27/22 1:45 PM | Sint-Truidense VV | KV Mechelen | 3-1 |
| 8/28/22 6:30 AM | KAA Gent | Royal Antwerp FC | 1-2 |
| 8/28/22 9:00 AM | KV Kortrijk | Standard Liège | 0-1 |
| 8/28/22 11:30 AM | Royale Union Saint-Gilloise | RSC Anderlecht | 2-1 |
| 8/28/22 2:00 PM | KVC Westerlo | KAS Eupen | 0-1 |