| Date | Home | Away | Result |
|---|---|---|---|
| 11/11/22 1:45 PM | OH Leuven | RFC Seraing | 5-0 |
| 11/12/22 9:00 AM | KVC Westerlo | KV Oostende | 6-0 |
| 11/12/22 11:15 AM | Sint-Truidense VV | KSV Cercle Brügge | 0-1 |
| 11/12/22 11:15 AM | SV Zulte-Waregem | KAS Eupen | 5-5 |
| 11/12/22 1:45 PM | Sporting Charleroi | KV Mechelen | 0-5 |
| 11/13/22 6:30 AM | Club Brugge | Royal Antwerp FC | 2-2 |
| 11/13/22 9:00 AM | Standard Liège | Royale Union Saint-Gilloise | 2-3 |
| 11/13/22 11:30 AM | RSC Anderlecht | KRC Genk | 0-2 |
| 11/13/22 2:00 PM | KV Kortrijk | KAA Gent | 0-4 |