| Date | Home | Away | Result |
|---|---|---|---|
| 10/7/22 1:45 PM | Royal Antwerp FC | Sint-Truidense VV | 2-0 |
| 10/8/22 9:00 AM | KRC Genk | KV Kortrijk | 2-1 |
| 10/8/22 11:15 AM | SV Zulte-Waregem | OH Leuven | 2-5 |
| 10/8/22 11:15 AM | RFC Seraing | KV Oostende | 1-1 |
| 10/8/22 1:45 PM | Club Brugge | KVC Westerlo | 0-2 |
| 10/9/22 6:30 AM | KV Mechelen | RSC Anderlecht | 1-3 |
| 10/9/22 9:00 AM | KAS Eupen | KAA Gent | 0-4 |
| 10/9/22 11:30 AM | Sporting Charleroi | Standard Liège | 0-1 |
| 10/9/22 2:00 PM | Royale Union Saint-Gilloise | KSV Cercle Brügge | 2-1 |