| Date | Home | Away | Result |
|---|---|---|---|
| 7/22/22 1:45 PM | Standard Liège | KAA Gent | 2-2 |
| 7/23/22 9:00 AM | Sporting Charleroi | KAS Eupen | 3-1 |
| 7/23/22 11:15 AM | SV Zulte-Waregem | RFC Seraing | 2-0 |
| 7/23/22 11:15 AM | KV Kortrijk | OH Leuven | 0-2 |
| 7/23/22 1:45 PM | Sint-Truidense VV | Royale Union Saint-Gilloise | 1-1 |
| 7/24/22 6:30 AM | Club Brugge | KRC Genk | 3-2 |
| 7/24/22 9:00 AM | KV Mechelen | Royal Antwerp FC | 0-2 |
| 7/24/22 11:30 AM | RSC Anderlecht | KV Oostende | 2-0 |
| 7/24/22 2:00 PM | KVC Westerlo | KSV Cercle Brügge | 2-0 |