Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/28/21 7:20 PM | 10/28/21 7:20 PM | Arizona Cardinals | Green Bay Packers | 21-24 | 3 - 10 points |
| 10/31/21 12:00 PM | 10/31/21 12:00 PM | Buffalo Bills | Miami Dolphins | 26-11 | 3 - 10 points |
| 10/31/21 12:00 PM | 10/31/21 12:00 PM | Atlanta Falcons | Carolina Panthers | 13-19 | 3 - 10 points |
| 10/31/21 12:00 PM | 10/31/21 12:00 PM | Chicago Bears | San Francisco 49ers | 22-33 | 3 - 10 points |
| 10/31/21 12:00 PM | 10/31/21 12:00 PM | Detroit Lions | Philadelphia Eagles | 6-44 | 3 - 10 points |
| 10/31/21 12:00 PM | 10/31/21 12:00 PM | Cleveland Browns | Pittsburgh Steelers | 10-15 | 3 - 10 points |
| 10/31/21 12:00 PM | 10/31/21 12:00 PM | Houston Texans | Los Angeles Rams | 22-38 | 3 - 10 points |
| 10/31/21 12:00 PM | 10/31/21 12:00 PM | Indianapolis Colts | Tennessee Titans | 31-34OT | 3 - 10 points |
| 10/31/21 12:00 PM | 10/31/21 12:00 PM | New York Jets | Cincinnati Bengals | 34-31 | 3 - 10 points |
| 10/31/21 3:05 PM | 10/31/21 3:05 PM | Seattle Seahawks | Jacksonville Jaguars | 31-7 | 3 - 10 points |
| 10/31/21 3:05 PM | 10/31/21 3:05 PM | Los Angeles Chargers | New England Patriots | 24-27 | 3 - 10 points |
| 10/31/21 3:25 PM | 10/31/21 3:25 PM | New Orleans Saints | Tampa Bay Buccaneers | 36-27 | 3 - 10 points |
| 10/31/21 3:25 PM | 10/31/21 3:25 PM | Denver Broncos | Washington Football Team | 17-10 | 3 - 10 points |
| 10/31/21 7:20 PM | 10/31/21 7:20 PM | Minnesota Vikings | Dallas Cowboys | 16-20 | 3 - 10 points |
| 11/1/21 7:15 PM | 11/1/21 7:15 PM | Kansas City Chiefs | New York Giants | 20-17 | 3 - 10 points |