Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 12/2/21 7:20 PM | 12/2/21 7:20 PM | New Orleans Saints | Dallas Cowboys | 17-27 | 3 - 10 points |
| 12/5/21 12:00 PM | 12/5/21 12:00 PM | Atlanta Falcons | Tampa Bay Buccaneers | 17-30 | 3 - 10 points |
| 12/5/21 12:00 PM | 12/5/21 12:00 PM | Cincinnati Bengals | Los Angeles Chargers | 22-41 | 3 - 10 points |
| 12/5/21 12:00 PM | 12/5/21 12:00 PM | Chicago Bears | Arizona Cardinals | 22-33 | 3 - 10 points |
| 12/5/21 12:00 PM | 12/5/21 12:00 PM | New York Jets | Philadelphia Eagles | 18-33 | 3 - 10 points |
| 12/5/21 12:00 PM | 12/5/21 12:00 PM | Detroit Lions | Minnesota Vikings | 29-27 | 3 - 10 points |
| 12/5/21 12:00 PM | 12/5/21 12:00 PM | Houston Texans | Indianapolis Colts | 0-31 | 3 - 10 points |
| 12/5/21 12:00 PM | 12/5/21 12:00 PM | Miami Dolphins | New York Giants | 20-9 | 3 - 10 points |
| 12/5/21 3:05 PM | 12/5/21 3:05 PM | Los Angeles Rams | Jacksonville Jaguars | 37-7 | 3 - 10 points |
| 12/5/21 3:05 PM | 12/5/21 3:05 PM | Las Vegas Raiders | Washington Football Team | 15-17 | 3 - 10 points |
| 12/5/21 3:25 PM | 12/5/21 3:25 PM | Seattle Seahawks | San Francisco 49ers | 30-23 | 3 - 10 points |
| 12/5/21 3:25 PM | 12/5/21 3:25 PM | Pittsburgh Steelers | Baltimore Ravens | 20-19 | 3 - 10 points |
| 12/5/21 7:20 PM | 12/5/21 7:20 PM | Kansas City Chiefs | Denver Broncos | 22-9 | 3 - 10 points |
| 12/6/21 7:15 PM | 12/6/21 7:15 PM | Buffalo Bills | New England Patriots | 10-14 | 3 - 10 points |