Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/9/21 7:20 PM | 9/9/21 7:20 PM | Tampa Bay Buccaneers | Dallas Cowboys | 31-29 | 3 - 10 points |
| 9/12/21 12:00 PM | 9/12/21 12:00 PM | Houston Texans | Jacksonville Jaguars | 37-21 | 3 - 10 points |
| 9/12/21 12:00 PM | 9/12/21 12:00 PM | Detroit Lions | San Francisco 49ers | 33-41 | 3 - 10 points |
| 9/12/21 12:00 PM | 9/12/21 12:00 PM | Cincinnati Bengals | Minnesota Vikings | 27-24OT | 3 - 10 points |
| 9/12/21 12:00 PM | 9/12/21 12:00 PM | Carolina Panthers | New York Jets | 19-14 | 3 - 10 points |
| 9/12/21 12:00 PM | 9/12/21 12:00 PM | Buffalo Bills | Pittsburgh Steelers | 16-23 | 3 - 10 points |
| 9/12/21 12:00 PM | 9/12/21 12:00 PM | Atlanta Falcons | Philadelphia Eagles | 6-32 | 3 - 10 points |
| 9/12/21 12:00 PM | 9/12/21 12:00 PM | Washington Football Team | Los Angeles Chargers | 16-20 | 3 - 10 points |
| 9/12/21 12:00 PM | 9/12/21 12:00 PM | Tennessee Titans | Arizona Cardinals | 13-38 | 3 - 10 points |
| 9/12/21 12:00 PM | 9/12/21 12:00 PM | Indianapolis Colts | Seattle Seahawks | 16-28 | 3 - 10 points |
| 9/12/21 3:25 PM | 9/12/21 3:25 PM | New York Giants | Denver Broncos | 13-27 | 3 - 10 points |
| 9/12/21 3:25 PM | 9/12/21 3:25 PM | New Orleans Saints | Green Bay Packers | 38-3 | 3 - 10 points |
| 9/12/21 3:25 PM | 9/12/21 3:25 PM | New England Patriots | Miami Dolphins | 16-17 | 3 - 10 points |
| 9/12/21 3:25 PM | 9/12/21 3:25 PM | Kansas City Chiefs | Cleveland Browns | 33-29 | 3 - 10 points |
| 9/12/21 7:20 PM | 9/12/21 7:20 PM | Los Angeles Rams | Chicago Bears | 34-14 | 3 - 10 points |
| 9/13/21 7:15 PM | 9/13/21 7:15 PM | Las Vegas Raiders | Baltimore Ravens | 33-27OT | 3 - 10 points |