Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 12/23/21 7:20 PM | 12/23/21 7:20 PM | Tennessee Titans | San Francisco 49ers | 20-17 | 4 - 10 - 4 |
| 12/25/21 3:30 PM | 12/25/21 3:30 PM | Green Bay Packers | Cleveland Browns | 24-22 | 3 - 10 - 10 |
| 12/25/21 7:15 PM | 12/25/21 7:15 PM | Arizona Cardinals | Indianapolis Colts | 16-22 | 4 - 10 - 4 |
| 12/26/21 12:00 PM | 12/26/21 12:00 PM | Cincinnati Bengals | Baltimore Ravens | 41-21 | 4 - 10 - 5 |
| 12/26/21 12:00 PM | 12/26/21 12:00 PM | Houston Texans | Los Angeles Chargers | 41-29 | 10 - 10 - 3 |
| 12/26/21 12:00 PM | 12/26/21 12:00 PM | Atlanta Falcons | Detroit Lions | 20-16 | 3 - 10 - 6 |
| 12/26/21 12:00 PM | 12/26/21 12:00 PM | New York Jets | Jacksonville Jaguars | 26-21 | 3 - 10 - 5 |
| 12/26/21 12:00 PM | 12/26/21 12:00 PM | Carolina Panthers | Tampa Bay Buccaneers | 6-32 | 10 - 10 - 3 |
| 12/26/21 12:00 PM | 12/26/21 12:00 PM | New England Patriots | Buffalo Bills | 21-33 | 4 - 10 - 5 |
| 12/26/21 12:00 PM | 12/26/21 12:00 PM | Minnesota Vikings | Los Angeles Rams | 23-30 | 7 - 10 - 3 |
| 12/26/21 12:00 PM | 12/26/21 12:00 PM | Philadelphia Eagles | New York Giants | 34-10 | 3 - 10 - 10 |
| 12/26/21 3:05 PM | 12/26/21 3:05 PM | Seattle Seahawks | Chicago Bears | 24-25 | 3 - 10 - 6 |
| 12/26/21 3:25 PM | 12/26/21 3:25 PM | Las Vegas Raiders | Denver Broncos | 17-13 | 3 - 10 - 5 |
| 12/26/21 3:25 PM | 12/26/21 3:25 PM | Kansas City Chiefs | Pittsburgh Steelers | 36-10 | 3 - 10 - 10 |
| 12/26/21 7:20 PM | 12/26/21 7:20 PM | Dallas Cowboys | Washington Football Team | 56-14 | 3 - 10 - 10 |
| 12/27/21 7:15 PM | 12/27/21 7:15 PM | New Orleans Saints | Miami Dolphins | 3-20 | 4 - 10 - 5 |