Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 12/16/21 7:20 PM | 12/16/21 7:20 PM | Los Angeles Chargers | Kansas City Chiefs | 28-34OT | 6 - 10 - 3 |
| 12/18/21 7:15 PM | 12/18/21 7:15 PM | Indianapolis Colts | New England Patriots | 27-17 | 5 - 10 - 4 |
| 12/19/21 12:00 PM | 12/19/21 12:00 PM | Buffalo Bills | Carolina Panthers | 31-14 | 3 - 10 - 10 |
| 12/19/21 12:00 PM | 12/19/21 12:00 PM | Miami Dolphins | New York Jets | 31-24 | 3 - 10 - 10 |
| 12/19/21 12:00 PM | 12/19/21 12:00 PM | Detroit Lions | Arizona Cardinals | 30-12 | 10 - 10 - 3 |
| 12/19/21 12:00 PM | 12/19/21 12:00 PM | Pittsburgh Steelers | Tennessee Titans | 19-13 | 4 - 10 - 4 |
| 12/19/21 12:00 PM | 12/19/21 12:00 PM | Jacksonville Jaguars | Houston Texans | 16-30 | 4 - 10 - 4 |
| 12/19/21 12:00 PM | 12/19/21 12:00 PM | New York Giants | Dallas Cowboys | 6-21 | 10 - 10 - 3 |
| 12/19/21 3:05 PM | 12/19/21 3:05 PM | San Francisco 49ers | Atlanta Falcons | 31-13 | 3 - 10 - 10 |
| 12/19/21 3:05 PM | 12/19/21 3:05 PM | Denver Broncos | Cincinnati Bengals | 10-15 | 4 - 10 - 4 |
| 12/19/21 3:25 PM | 12/19/21 3:25 PM | Baltimore Ravens | Green Bay Packers | 30-31 | 8 - 10 - 3 |
| 12/19/21 7:20 PM | 12/19/21 7:20 PM | Tampa Bay Buccaneers | New Orleans Saints | 0-9 | 3 - 10 - 10 |
| 12/20/21 4:00 PM | 12/20/21 4:00 PM | Cleveland Browns | Las Vegas Raiders | 14-16 | 3 - 10 - 6 |
| 12/20/21 7:15 PM | 12/20/21 7:15 PM | Chicago Bears | Minnesota Vikings | 9-17 | 6 - 10 - 3 |
| 12/21/21 6:00 PM | 12/21/21 6:00 PM | Philadelphia Eagles | Washington Football Team | 27-17 | 4 - 10 - 5 |
| 12/21/21 6:00 PM | 12/21/21 6:00 PM | Los Angeles Rams | Seattle Seahawks | 20-10 | 3 - 10 - 10 |