Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 12/9/21 7:20 PM | 12/9/21 7:20 PM | Minnesota Vikings | Pittsburgh Steelers | 36-28 | 4 - 10 - 5 |
| 12/12/21 12:00 PM | 12/12/21 12:00 PM | Cleveland Browns | Baltimore Ravens | 24-22 | 5 - 10 - 4 |
| 12/12/21 12:00 PM | 12/12/21 12:00 PM | Carolina Panthers | Atlanta Falcons | 21-29 | 4 - 10 - 5 |
| 12/12/21 12:00 PM | 12/12/21 12:00 PM | New York Jets | New Orleans Saints | 9-30 | 7 - 10 - 3 |
| 12/12/21 12:00 PM | 12/12/21 12:00 PM | Kansas City Chiefs | Las Vegas Raiders | 48-9 | 3 - 10 - 10 |
| 12/12/21 12:00 PM | 12/12/21 12:00 PM | Houston Texans | Seattle Seahawks | 13-33 | 10 - 10 - 3 |
| 12/12/21 12:00 PM | 12/12/21 12:00 PM | Tennessee Titans | Jacksonville Jaguars | 20-0 | 3 - 10 - 10 |
| 12/12/21 12:00 PM | 12/12/21 12:00 PM | Washington Football Team | Dallas Cowboys | 20-27 | 6 - 10 - 3 |
| 12/12/21 3:05 PM | 12/12/21 3:05 PM | Denver Broncos | Detroit Lions | 38-10 | 3 - 10 - 10 |
| 12/12/21 3:05 PM | 12/12/21 3:05 PM | Los Angeles Chargers | New York Giants | 37-21 | 3 - 10 - 10 |
| 12/12/21 3:25 PM | 12/12/21 3:25 PM | Tampa Bay Buccaneers | Buffalo Bills | 33-27OT | 3 - 10 - 7 |
| 12/12/21 3:25 PM | 12/12/21 3:25 PM | Cincinnati Bengals | San Francisco 49ers | 23-26OT | 4 - 10 - 4 |
| 12/12/21 7:20 PM | 12/12/21 7:20 PM | Green Bay Packers | Chicago Bears | 45-30 | 3 - 10 - 10 |
| 12/13/21 7:15 PM | 12/13/21 7:15 PM | Arizona Cardinals | Los Angeles Rams | 23-30 | 3 - 10 - 6 |