Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 11/25/21 11:30 AM | 11/25/21 11:30 AM | Detroit Lions | Chicago Bears | 14-16 | 5 - 10 - 3 |
| 11/25/21 3:30 PM | 11/25/21 3:30 PM | Dallas Cowboys | Las Vegas Raiders | 33-36OT | 3 - 10 - 10 |
| 11/25/21 7:20 PM | 11/25/21 7:20 PM | New Orleans Saints | Buffalo Bills | 6-31 | 6 - 10 - 3 |
| 11/28/21 12:00 PM | 11/28/21 12:00 PM | Jacksonville Jaguars | Atlanta Falcons | 14-21 | 4 - 10 - 4 |
| 11/28/21 12:00 PM | 11/28/21 12:00 PM | Cincinnati Bengals | Pittsburgh Steelers | 41-10 | 4 - 10 - 5 |
| 11/28/21 12:00 PM | 11/28/21 12:00 PM | New England Patriots | Tennessee Titans | 36-13 | 3 - 10 - 6 |
| 11/28/21 12:00 PM | 11/28/21 12:00 PM | Miami Dolphins | Carolina Panthers | 33-10 | 5 - 10 - 4 |
| 11/28/21 12:00 PM | 11/28/21 12:00 PM | New York Giants | Philadelphia Eagles | 13-7 | 8 - 10 - 3 |
| 11/28/21 12:00 PM | 11/28/21 12:00 PM | Houston Texans | New York Jets | 14-21 | 3 - 10 - 7 |
| 11/28/21 12:00 PM | 11/28/21 12:00 PM | Indianapolis Colts | Tampa Bay Buccaneers | 31-38 | 5 - 10 - 4 |
| 11/28/21 3:05 PM | 11/28/21 3:05 PM | Denver Broncos | Los Angeles Chargers | 28-13 | 8 - 10 - 3 |
| 11/28/21 3:25 PM | 11/28/21 3:25 PM | San Francisco 49ers | Minnesota Vikings | 34-26 | 4 - 10 - 4 |
| 11/28/21 3:25 PM | 11/28/21 3:25 PM | Green Bay Packers | Los Angeles Rams | 36-28 | 4 - 10 - 4 |
| 11/28/21 7:20 PM | 11/28/21 7:20 PM | Baltimore Ravens | Cleveland Browns | 16-10 | 3 - 10 - 8 |
| 11/29/21 7:15 PM | 11/29/21 7:15 PM | Washington Football Team | Seattle Seahawks | 17-15 | 4 - 10 - 4 |