Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 4/23/22 2:00 PM | 4/23/22 2:00 PM | Philadelphia Union | CF Montreal | 1-1 | 5 - 7 points |
| 4/23/22 2:00 PM | 4/23/22 2:00 PM | FC Dallas | Houston Dynamo | 2-1 | 5 - 7 points |
| 4/23/22 4:00 PM | 4/23/22 4:00 PM | Minnesota United FC | Chicago Fire | 3-0 | 5 - 7 points |
| 4/23/22 6:30 PM | 4/23/22 6:30 PM | D.C. United | New England Revolution | 3-2 | 5 - 7 points |
| 4/23/22 7:30 PM | 4/23/22 7:30 PM | Austin FC | Vancouver Whitecaps | 3-0 | 5 - 7 points |
| 4/23/22 7:30 PM | 4/23/22 7:30 PM | Sporting Kansas City | Columbus Crew | 0-0 | 5 - 7 points |
| 4/23/22 8:00 PM | 4/23/22 8:00 PM | Colorado Rapids | Charlotte FC | 0-0 | 5 - 7 points |
| 4/23/22 9:00 PM | 4/23/22 9:00 PM | Portland Timbers | Real Salt Lake | 0-0 | 5 - 7 points |
| 4/23/22 9:00 PM | 4/23/22 9:00 PM | San Jose Earthquakes | Seattle Sounders | 4-3 | 5 - 7 points |
| 4/23/22 9:30 PM | 4/23/22 9:30 PM | Los Angeles Galaxy | Nashville SC | 1-0 | 5 - 7 points |
| 4/24/22 12:00 PM | 4/24/22 12:00 PM | Inter Miami CF | Atlanta United FC | 2-1 | 5 - 7 points |
| 4/24/22 2:30 PM | 4/24/22 2:30 PM | Orlando City | New York Red Bulls | 0-3 | 5 - 7 points |
| 4/24/22 4:00 PM | 4/24/22 4:00 PM | Cincinnati FC | Los Angeles FC | 1-2 | 5 - 7 points |
| 4/24/22 4:00 PM | 4/24/22 4:00 PM | New York City FC | Toronto FC | 5-4 | 5 - 7 points |