Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 4/16/22 2:00 PM | 4/16/22 2:00 PM | CF Montreal | Vancouver Whitecaps | 2-1 | 5 - 7 points |
| 4/16/22 2:30 PM | 4/16/22 2:30 PM | San Jose Earthquakes | Nashville SC | 2-2 | 5 - 7 points |
| 4/16/22 5:00 PM | 4/16/22 5:00 PM | Houston Dynamo | Portland Timbers | 0-0 | 5 - 7 points |
| 4/16/22 5:00 PM | 4/16/22 5:00 PM | Atlanta United FC | Cincinnati FC | 0-0 | 5 - 7 points |
| 4/16/22 6:00 PM | 4/16/22 6:00 PM | New York Red Bulls | FC Dallas | 0-0 | 5 - 7 points |
| 4/16/22 6:30 PM | 4/16/22 6:30 PM | Toronto FC | Philadelphia Union | 2-1 | 5 - 7 points |
| 4/16/22 6:30 PM | 4/16/22 6:30 PM | D.C. United | Austin FC | 2-3 | 5 - 7 points |
| 4/16/22 6:30 PM | 4/16/22 6:30 PM | Columbus Crew | Orlando City | 0-2 | 5 - 7 points |
| 4/16/22 6:30 PM | 4/16/22 6:30 PM | New England Revolution | Charlotte FC | 2-1 | 5 - 7 points |
| 4/16/22 7:00 PM | 4/16/22 7:00 PM | Minnesota United FC | Colorado Rapids | 3-1 | 5 - 7 points |
| 4/16/22 7:00 PM | 4/16/22 7:00 PM | Chicago Fire | Los Angeles Galaxy | 0-0 | 5 - 7 points |
| 4/16/22 9:00 PM | 4/16/22 9:00 PM | Seattle Sounders | Inter Miami CF | 0-1 | 5 - 7 points |
| 4/17/22 12:00 PM | 4/17/22 12:00 PM | New York City FC | Real Salt Lake | 6-0 | 5 - 7 points |
| 4/17/22 3:00 PM | 4/17/22 3:00 PM | Los Angeles FC | Sporting Kansas City | 3-1 | 5 - 7 points |