Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 4/9/22 12:00 PM | 4/9/22 12:00 PM | Orlando City | Chicago Fire | 1-0 | 5 - 7 points |
| 4/9/22 2:00 PM | 4/9/22 2:00 PM | Inter Miami CF | New England Revolution | 3-2 | 5 - 7 points |
| 4/9/22 3:00 PM | 4/9/22 3:00 PM | New York Red Bulls | CF Montreal | 1-2 | 5 - 7 points |
| 4/9/22 5:00 PM | 4/9/22 5:00 PM | Philadelphia Union | Columbus Crew | 1-0 | 5 - 7 points |
| 4/9/22 6:30 PM | 4/9/22 6:30 PM | Los Angeles Galaxy | Los Angeles FC | 2-1 | 5 - 7 points |
| 4/9/22 7:00 PM | 4/9/22 7:00 PM | Real Salt Lake | Toronto FC | 2-2 | 5 - 7 points |
| 4/9/22 7:30 PM | 4/9/22 7:30 PM | FC Dallas | Colorado Rapids | 3-1 | 5 - 7 points |
| 4/9/22 7:30 PM | 4/9/22 7:30 PM | Houston Dynamo | San Jose Earthquakes | 4-3 | 5 - 7 points |
| 4/9/22 7:30 PM | 4/9/22 7:30 PM | Sporting Kansas City | Nashville SC | 1-2 | 5 - 7 points |
| 4/9/22 9:00 PM | 4/9/22 9:00 PM | Vancouver Whitecaps | Portland Timbers | 2-3 | 5 - 7 points |
| 4/10/22 12:30 PM | 4/10/22 12:30 PM | Charlotte FC | Atlanta United FC | 1-0 | 5 - 7 points |
| 4/10/22 6:30 PM | 4/10/22 6:30 PM | Austin FC | Minnesota United FC | 1-0 | 5 - 7 points |
| 8/31/22 7:00 PM | 8/31/22 7:00 PM | New York City FC | D.C. United | 1-2 | 5 - 7 points |
| 9/27/22 9:00 PM | 9/27/22 9:00 PM | Seattle Sounders | Cincinnati FC | 1-1 | 5 - 7 points |