Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 4/2/22 2:30 PM | 4/2/22 2:30 PM | Chicago Fire | FC Dallas | 0-0 | 5 - 7 points |
| 4/2/22 3:00 PM | 4/2/22 3:00 PM | Cincinnati FC | CF Montreal | 3-4 | 5 - 7 points |
| 4/2/22 3:00 PM | 4/2/22 3:00 PM | Toronto FC | New York City FC | 2-1 | 5 - 7 points |
| 4/2/22 5:00 PM | 4/2/22 5:00 PM | Columbus Crew | Nashville SC | 0-1 | 5 - 7 points |
| 4/2/22 6:30 PM | 4/2/22 6:30 PM | New England Revolution | New York Red Bulls | 0-1 | 5 - 7 points |
| 4/2/22 6:30 PM | 4/2/22 6:30 PM | Orlando City | Los Angeles FC | 2-4 | 5 - 7 points |
| 4/2/22 6:30 PM | 4/2/22 6:30 PM | San Jose Earthquakes | Austin FC | 2-2 | 5 - 7 points |
| 4/2/22 6:30 PM | 4/2/22 6:30 PM | D.C. United | Atlanta United FC | 0-1 | 5 - 7 points |
| 4/2/22 6:30 PM | 4/2/22 6:30 PM | Philadelphia Union | Charlotte FC | 2-0 | 5 - 7 points |
| 4/2/22 7:00 PM | 4/2/22 7:00 PM | Vancouver Whitecaps | Sporting Kansas City | 1-0 | 5 - 7 points |
| 4/2/22 7:00 PM | 4/2/22 7:00 PM | Minnesota United FC | Seattle Sounders | 1-2 | 5 - 7 points |
| 4/2/22 7:00 PM | 4/2/22 7:00 PM | Inter Miami CF | Houston Dynamo | 1-3 | 5 - 7 points |
| 4/2/22 8:00 PM | 4/2/22 8:00 PM | Colorado Rapids | Real Salt Lake | 1-1 | 5 - 7 points |
| 4/3/22 3:30 PM | 4/3/22 3:30 PM | Portland Timbers | Los Angeles Galaxy | 1-3 | 5 - 7 points |