Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 3/19/22 12:00 PM | 3/19/22 12:00 PM | New York City FC | Philadelphia Union | 0-2 | 5 - 7 points |
| 3/19/22 12:00 PM | 3/19/22 12:00 PM | Cincinnati FC | Inter Miami CF | 3-1 | 5 - 7 points |
| 3/19/22 2:00 PM | 3/19/22 2:00 PM | Toronto FC | D.C. United | 2-1 | 5 - 7 points |
| 3/19/22 2:30 PM | 3/19/22 2:30 PM | Los Angeles Galaxy | Orlando City | 0-1 | 5 - 7 points |
| 3/19/22 3:00 PM | 3/19/22 3:00 PM | Atlanta United FC | CF Montreal | 3-3 | 5 - 7 points |
| 3/19/22 5:00 PM | 3/19/22 5:00 PM | Chicago Fire | Sporting Kansas City | 3-1 | 5 - 7 points |
| 3/19/22 6:00 PM | 3/19/22 6:00 PM | Charlotte FC | New England Revolution | 3-1 | 5 - 7 points |
| 3/19/22 7:00 PM | 3/19/22 7:00 PM | Minnesota United FC | San Jose Earthquakes | 1-0 | 5 - 7 points |
| 3/19/22 7:30 PM | 3/19/22 7:30 PM | FC Dallas | Portland Timbers | 4-1 | 5 - 7 points |
| 3/19/22 7:30 PM | 3/19/22 7:30 PM | Houston Dynamo | Colorado Rapids | 1-1 | 5 - 7 points |
| 3/19/22 8:30 PM | 3/19/22 8:30 PM | Real Salt Lake | Nashville SC | 2-1 | 5 - 7 points |
| 3/20/22 1:00 PM | 3/20/22 1:00 PM | New York Red Bulls | Columbus Crew | 1-1 | 5 - 7 points |
| 3/20/22 3:30 PM | 3/20/22 3:30 PM | Austin FC | Seattle Sounders | 1-1 | 5 - 7 points |
| 3/20/22 9:00 PM | 3/20/22 9:00 PM | Los Angeles FC | Vancouver Whitecaps | 3-1 | 5 - 7 points |