Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/30/22 6:30 PM | 9/30/22 6:30 PM | Toronto FC | Inter Miami CF | 0-1 | 5 - 7 points |
| 10/1/22 12:30 PM | 10/1/22 12:30 PM | New England Revolution | Atlanta United FC | 2-1 | 5 - 7 points |
| 10/1/22 2:30 PM | 10/1/22 2:30 PM | Colorado Rapids | FC Dallas | 1-0 | 5 - 7 points |
| 10/1/22 4:30 PM | 10/1/22 4:30 PM | Charlotte FC | Philadelphia Union | 4-0 | 5 - 7 points |
| 10/1/22 6:30 PM | 10/1/22 6:30 PM | Columbus Crew | New York Red Bulls | 2-1 | 5 - 7 points |
| 10/1/22 6:30 PM | 10/1/22 6:30 PM | CF Montreal | D.C. United | 1-0 | 5 - 7 points |
| 10/1/22 6:30 PM | 10/1/22 6:30 PM | Cincinnati FC | Chicago Fire | 2-3 | 5 - 7 points |
| 10/1/22 9:00 PM | 10/1/22 9:00 PM | San Jose Earthquakes | Minnesota United FC | 2-0 | 5 - 7 points |
| 10/1/22 9:00 PM | 10/1/22 9:00 PM | Vancouver Whitecaps | Austin FC | 2-0 | 5 - 7 points |
| 10/1/22 9:30 PM | 10/1/22 9:30 PM | Los Angeles Galaxy | Real Salt Lake | 1-1 | 5 - 7 points |
| 10/2/22 12:00 PM | 10/2/22 12:00 PM | New York City FC | Orlando City | 2-1 | 5 - 7 points |
| 10/2/22 2:00 PM | 10/2/22 2:00 PM | Portland Timbers | Los Angeles FC | 1-2 | 5 - 7 points |
| 10/2/22 4:00 PM | 10/2/22 4:00 PM | Sporting Kansas City | Seattle Sounders | 1-0 | 5 - 7 points |
| 10/2/22 7:30 PM | 10/2/22 7:30 PM | Nashville SC | Houston Dynamo | 1-2 | 5 - 7 points |