Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/17/22 12:00 PM | 9/17/22 12:00 PM | New York City FC | New York Red Bulls | 2-0 | 5 - 7 points |
| 9/17/22 2:30 PM | 9/17/22 2:30 PM | Atlanta United FC | Philadelphia Union | 0-0 | 5 - 7 points |
| 9/17/22 6:30 PM | 9/17/22 6:30 PM | New England Revolution | CF Montreal | 0-1 | 5 - 7 points |
| 9/17/22 6:30 PM | 9/17/22 6:30 PM | Orlando City | Toronto FC | 4-0 | 5 - 7 points |
| 9/17/22 7:00 PM | 9/17/22 7:00 PM | Chicago Fire | Charlotte FC | 2-3 | 5 - 7 points |
| 9/17/22 7:30 PM | 9/17/22 7:30 PM | Sporting Kansas City | Minnesota United FC | 4-1 | 5 - 7 points |
| 9/17/22 8:00 PM | 9/17/22 8:00 PM | Austin FC | Nashville SC | 1-1 | 5 - 7 points |
| 9/17/22 8:30 PM | 9/17/22 8:30 PM | Real Salt Lake | Cincinnati FC | 1-2 | 5 - 7 points |
| 9/17/22 9:00 PM | 9/17/22 9:00 PM | Vancouver Whitecaps | Seattle Sounders | 2-1 | 5 - 7 points |
| 9/17/22 9:30 PM | 9/17/22 9:30 PM | San Jose Earthquakes | FC Dallas | 1-1 | 5 - 7 points |
| 9/17/22 9:30 PM | 9/17/22 9:30 PM | Los Angeles Galaxy | Colorado Rapids | 4-1 | 5 - 7 points |
| 9/18/22 12:00 PM | 9/18/22 12:00 PM | Columbus Crew | Portland Timbers | 1-1 | 5 - 7 points |
| 9/18/22 4:00 PM | 9/18/22 4:00 PM | D.C. United | Inter Miami CF | 2-3 | 5 - 7 points |
| 9/18/22 9:30 PM | 9/18/22 9:30 PM | Los Angeles FC | Houston Dynamo | 3-1 | 5 - 7 points |