Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/13/22 6:30 PM | 9/13/22 6:30 PM | CF Montreal | Chicago Fire | 3-2 | 5 - 7 points |
| 9/13/22 7:00 PM | 9/13/22 7:00 PM | Minnesota United FC | Los Angeles FC | 1-1 | 5 - 7 points |
| 9/13/22 7:00 PM | 9/13/22 7:00 PM | Inter Miami CF | Columbus Crew | 2-1 | 5 - 7 points |
| 9/13/22 7:30 PM | 9/13/22 7:30 PM | Houston Dynamo | New England Revolution | 3-1 | 5 - 7 points |
| 9/13/22 7:30 PM | 9/13/22 7:30 PM | Sporting Kansas City | D.C. United | 3-0 | 5 - 7 points |
| 9/14/22 5:00 PM | 9/14/22 5:00 PM | Orlando City | Atlanta United FC | 0-1 | 5 - 7 points |
| 9/14/22 8:15 PM | 9/14/22 8:15 PM | Austin FC | Real Salt Lake | 3-0 | 5 - 7 points |
| 9/14/22 9:00 PM | 9/14/22 9:00 PM | Vancouver Whitecaps | Los Angeles Galaxy | 3-0 | 5 - 7 points |
| 9/14/22 9:00 PM | 9/14/22 9:00 PM | Colorado Rapids | San Jose Earthquakes | 2-1 | 5 - 7 points |