Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/9/22 6:30 PM | 9/9/22 6:30 PM | CF Montreal | Columbus Crew | 2-2 | 5 - 7 points |
| 9/10/22 12:00 PM | 9/10/22 12:00 PM | Charlotte FC | New York City FC | 1-0 | 5 - 7 points |
| 9/10/22 2:30 PM | 9/10/22 2:30 PM | Nashville SC | Los Angeles Galaxy | 1-1 | 5 - 7 points |
| 9/10/22 5:00 PM | 9/10/22 5:00 PM | New York Red Bulls | New England Revolution | 2-1 | 5 - 7 points |
| 9/10/22 6:30 PM | 9/10/22 6:30 PM | Cincinnati FC | San Jose Earthquakes | 6-0 | 5 - 7 points |
| 9/10/22 6:30 PM | 9/10/22 6:30 PM | Atlanta United FC | Toronto FC | 4-2 | 5 - 7 points |
| 9/10/22 6:30 PM | 9/10/22 6:30 PM | Philadelphia Union | Orlando City | 5-1 | 5 - 7 points |
| 9/10/22 7:00 PM | 9/10/22 7:00 PM | Chicago Fire | Inter Miami CF | 3-1 | 5 - 7 points |
| 9/10/22 7:00 PM | 9/10/22 7:00 PM | Seattle Sounders | Austin FC | 3-0 | 5 - 7 points |
| 9/10/22 7:30 PM | 9/10/22 7:30 PM | FC Dallas | Los Angeles FC | 2-1 | 5 - 7 points |
| 9/10/22 7:30 PM | 9/10/22 7:30 PM | Houston Dynamo | Sporting Kansas City | 0-0 | 5 - 7 points |
| 9/10/22 8:30 PM | 9/10/22 8:30 PM | Colorado Rapids | Vancouver Whitecaps | 3-1 | 5 - 7 points |
| 9/10/22 8:30 PM | 9/10/22 8:30 PM | Real Salt Lake | D.C. United | 0-0 | 5 - 7 points |
| 9/10/22 9:00 PM | 9/10/22 9:00 PM | Portland Timbers | Minnesota United FC | 1-0 | 5 - 7 points |