Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/3/22 2:30 PM | 9/3/22 2:30 PM | Minnesota United FC | FC Dallas | 0-3 | 5 - 7 points |
| 9/3/22 4:30 PM | 9/3/22 4:30 PM | Columbus Crew | Chicago Fire | 0-0 | 5 - 7 points |
| 9/3/22 6:00 PM | 9/3/22 6:00 PM | New York Red Bulls | Philadelphia Union | 0-2 | 5 - 7 points |
| 9/3/22 6:30 PM | 9/3/22 6:30 PM | Cincinnati FC | Charlotte FC | 2-0 | 5 - 7 points |
| 9/3/22 7:30 PM | 9/3/22 7:30 PM | Nashville SC | Austin FC | 3-0 | 5 - 7 points |
| 9/4/22 4:30 PM | 9/4/22 4:30 PM | Portland Timbers | Atlanta United FC | 2-1 | 5 - 7 points |
| 9/4/22 6:30 PM | 9/4/22 6:30 PM | Toronto FC | CF Montreal | 3-4 | 5 - 7 points |
| 9/4/22 6:30 PM | 9/4/22 6:30 PM | D.C. United | Colorado Rapids | 0-0 | 5 - 7 points |
| 9/4/22 7:00 PM | 9/4/22 7:00 PM | Los Angeles Galaxy | Sporting Kansas City | 2-2 | 5 - 7 points |
| 9/4/22 7:00 PM | 9/4/22 7:00 PM | New England Revolution | New York City FC | 3-0 | 5 - 7 points |
| 9/4/22 8:00 PM | 9/4/22 8:00 PM | Seattle Sounders | Houston Dynamo | 2-1 | 5 - 7 points |
| 9/4/22 8:30 PM | 9/4/22 8:30 PM | San Jose Earthquakes | Vancouver Whitecaps | 2-0 | 5 - 7 points |
| 9/4/22 9:30 PM | 9/4/22 9:30 PM | Los Angeles FC | Real Salt Lake | 2-0 | 5 - 7 points |
| 9/7/22 7:00 PM | 9/7/22 7:00 PM | New York City FC | Cincinnati FC | 1-1 | 5 - 7 points |
| 10/5/22 7:00 PM | 10/5/22 7:00 PM | Inter Miami CF | Orlando City | 4-1 | 5 - 7 points |