Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/22/21 7:00 PM | 9/22/21 7:00 PM | Chicago Fire | New England Revolution | 2-3 | 5 - 7 points |
| 10/30/21 12:30 PM | 10/30/21 12:30 PM | Inter Miami CF | New York City FC | 1-3 | 5 - 7 points |
| 10/30/21 2:30 PM | 10/30/21 2:30 PM | Real Salt Lake | San Jose Earthquakes | 3-4 | 5 - 7 points |
| 10/30/21 3:00 PM | 10/30/21 3:00 PM | New York Red Bulls | CF Montreal | 1-0 | 5 - 7 points |
| 10/30/21 5:00 PM | 10/30/21 5:00 PM | Atlanta United FC | Toronto FC | 1-1 | 5 - 7 points |
| 10/30/21 6:30 PM | 10/30/21 6:30 PM | D.C. United | Columbus Crew | 1-3 | 5 - 7 points |
| 10/30/21 8:00 PM | 10/30/21 8:00 PM | FC Dallas | Austin FC | 2-1 | 5 - 7 points |
| 10/31/21 12:00 PM | 10/31/21 12:00 PM | Minnesota United FC | Sporting Kansas City | 2-1 | 5 - 7 points |
| 10/31/21 2:00 PM | 10/31/21 2:00 PM | Houston Dynamo | Colorado Rapids | 0-1 | 5 - 7 points |
| 10/31/21 3:00 PM | 10/31/21 3:00 PM | Orlando City | Nashville SC | 1-1 | 5 - 7 points |
| 10/31/21 6:30 PM | 10/31/21 6:30 PM | Philadelphia Union | Cincinnati FC | 2-0 | 5 - 7 points |
| 11/1/21 9:00 PM | 11/1/21 9:00 PM | Seattle Sounders | Los Angeles Galaxy | 1-1 | 5 - 7 points |
| 11/2/21 9:30 PM | 11/2/21 9:30 PM | Los Angeles FC | Vancouver Whitecaps | 1-1 | 5 - 7 points |