| Date | Dead line | Home | Away | Result | Points rule |
|---|
| 10/26/21 9:30 PM | 10/26/21 9:30 PM | Los Angeles FC | Seattle Sounders | 3-0 | 5 - 7 points |
| 10/27/21 6:00 PM | 10/27/21 6:00 PM | New England Revolution | Colorado Rapids | 1-0 | 5 - 7 points |
| 10/27/21 6:30 PM | 10/27/21 6:30 PM | Toronto FC | Philadelphia Union | 2-2 | 5 - 7 points |
| 10/27/21 6:30 PM | 10/27/21 6:30 PM | Columbus Crew | Orlando City | 3-2 | 5 - 7 points |
| 10/27/21 6:30 PM | 10/27/21 6:30 PM | Cincinnati FC | Nashville SC | 3-6 | 5 - 7 points |
| 10/27/21 6:30 PM | 10/27/21 6:30 PM | Atlanta United FC | Inter Miami CF | 2-1 | 5 - 7 points |
| 10/27/21 6:30 PM | 10/27/21 6:30 PM | D.C. United | New York Red Bulls | 1-0 | 5 - 7 points |
| 10/27/21 6:30 PM | 10/27/21 6:30 PM | New York City FC | Chicago Fire | 1-0 | 5 - 7 points |
| 10/27/21 7:00 PM | 10/27/21 7:00 PM | FC Dallas | Real Salt Lake | 1-2 | 5 - 7 points |
| 10/27/21 7:30 PM | 10/27/21 7:30 PM | Sporting Kansas City | Los Angeles Galaxy | 2-0 | 5 - 7 points |
| 10/27/21 9:00 PM | 10/27/21 9:00 PM | Portland Timbers | San Jose Earthquakes | 2-0 | 5 - 7 points |
| 10/27/21 9:00 PM | 10/27/21 9:00 PM | Vancouver Whitecaps | Minnesota United FC | 2-1 | 5 - 7 points |