Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 8/26/22 7:00 PM | 8/26/22 7:00 PM | Austin FC | Los Angeles FC | 4-1 | 5 - 7 points |
| 8/26/22 9:00 PM | 8/26/22 9:00 PM | Portland Timbers | Seattle Sounders | 2-1 | 5 - 7 points |
| 8/27/22 2:30 PM | 8/27/22 2:30 PM | Minnesota United FC | Houston Dynamo | 2-1 | 5 - 7 points |
| 8/27/22 6:00 PM | 8/27/22 6:00 PM | New York Red Bulls | Inter Miami CF | 3-1 | 5 - 7 points |
| 8/27/22 6:00 PM | 8/27/22 6:00 PM | Charlotte FC | Toronto FC | 0-2 | 5 - 7 points |
| 8/27/22 6:30 PM | 8/27/22 6:30 PM | Philadelphia Union | Colorado Rapids | 6-0 | 5 - 7 points |
| 8/27/22 6:30 PM | 8/27/22 6:30 PM | Cincinnati FC | Columbus Crew | 2-2 | 5 - 7 points |
| 8/27/22 7:00 PM | 8/27/22 7:00 PM | Chicago Fire | CF Montreal | 0-2 | 5 - 7 points |
| 8/27/22 7:30 PM | 8/27/22 7:30 PM | Sporting Kansas City | San Jose Earthquakes | 1-0 | 5 - 7 points |
| 8/27/22 8:00 PM | 8/27/22 8:00 PM | FC Dallas | Real Salt Lake | 1-1 | 5 - 7 points |
| 8/27/22 9:00 PM | 8/27/22 9:00 PM | Vancouver Whitecaps | Nashville SC | 0-3 | 5 - 7 points |
| 8/28/22 3:00 PM | 8/28/22 3:00 PM | Atlanta United FC | D.C. United | 3-2 | 5 - 7 points |
| 8/28/22 6:30 PM | 8/28/22 6:30 PM | Orlando City | New York City FC | 2-1 | 5 - 7 points |
| 8/28/22 7:00 PM | 8/28/22 7:00 PM | New England Revolution | Los Angeles Galaxy | 1-2 | 5 - 7 points |