Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/23/21 2:30 PM | 10/23/21 2:30 PM | Seattle Sounders | Sporting Kansas City | 1-2 | 5 - 7 points |
| 10/23/21 5:00 PM | 10/23/21 5:00 PM | Columbus Crew | New York Red Bulls | 1-2 | 5 - 7 points |
| 10/23/21 6:30 PM | 10/23/21 6:30 PM | Toronto FC | CF Montreal | 1-1 | 5 - 7 points |
| 10/23/21 6:30 PM | 10/23/21 6:30 PM | Philadelphia Union | Nashville SC | 1-0 | 5 - 7 points |
| 10/23/21 6:30 PM | 10/23/21 6:30 PM | New York City FC | D.C. United | 6-0 | 5 - 7 points |
| 10/23/21 7:00 PM | 10/23/21 7:00 PM | Inter Miami CF | Cincinnati FC | 5-1 | 5 - 7 points |
| 10/23/21 7:00 PM | 10/23/21 7:00 PM | Chicago Fire | Real Salt Lake | 1-0 | 5 - 7 points |
| 10/23/21 7:00 PM | 10/23/21 7:00 PM | Minnesota United FC | Los Angeles FC | 1-1 | 5 - 7 points |
| 10/23/21 8:00 PM | 10/23/21 8:00 PM | Colorado Rapids | Portland Timbers | 2-0 | 5 - 7 points |
| 10/23/21 9:00 PM | 10/23/21 9:00 PM | San Jose Earthquakes | Vancouver Whitecaps | 1-1 | 5 - 7 points |
| 10/23/21 9:00 PM | 10/23/21 9:00 PM | Los Angeles Galaxy | FC Dallas | 2-2 | 5 - 7 points |
| 10/24/21 4:00 PM | 10/24/21 4:00 PM | Austin FC | Houston Dynamo | 2-1 | 5 - 7 points |
| 10/24/21 6:30 PM | 10/24/21 6:30 PM | Orlando City | New England Revolution | 2-2 | 5 - 7 points |