Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/20/21 6:30 PM | 10/20/21 6:30 PM | Orlando City | CF Montreal | 1-1 | 5 - 7 points |
| 10/20/21 6:30 PM | 10/20/21 6:30 PM | Inter Miami CF | Toronto FC | 3-0 | 5 - 7 points |
| 10/20/21 6:30 PM | 10/20/21 6:30 PM | Atlanta United FC | New York City FC | 1-1 | 5 - 7 points |
| 10/20/21 6:30 PM | 10/20/21 6:30 PM | D.C. United | New England Revolution | 2-3 | 5 - 7 points |
| 10/20/21 6:30 PM | 10/20/21 6:30 PM | Cincinnati FC | Chicago Fire | 3-4 | 5 - 7 points |
| 10/20/21 7:00 PM | 10/20/21 7:00 PM | FC Dallas | Los Angeles FC | 2-3 | 5 - 7 points |
| 10/20/21 7:00 PM | 10/20/21 7:00 PM | Minnesota United FC | Philadelphia Union | 3-2 | 5 - 7 points |
| 10/20/21 7:30 PM | 10/20/21 7:30 PM | Nashville SC | Columbus Crew | 1-1 | 5 - 7 points |
| 10/20/21 7:30 PM | 10/20/21 7:30 PM | Houston Dynamo | Los Angeles Galaxy | 0-3 | 5 - 7 points |
| 10/20/21 8:00 PM | 10/20/21 8:00 PM | Colorado Rapids | Seattle Sounders | 1-1 | 5 - 7 points |
| 10/20/21 9:00 PM | 10/20/21 9:00 PM | Portland Timbers | Vancouver Whitecaps | 2-3 | 5 - 7 points |
| 10/20/21 9:30 PM | 10/20/21 9:30 PM | San Jose Earthquakes | Austin FC | 4-0 | 5 - 7 points |