Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 3/12/22 12:00 PM | 3/12/22 12:00 PM | New York City FC | CF Montreal | 4-1 | 5 - 7 points |
| 3/12/22 12:30 PM | 3/12/22 12:30 PM | Columbus Crew | Toronto FC | 2-1 | 5 - 7 points |
| 3/12/22 12:30 PM | 3/12/22 12:30 PM | Inter Miami CF | Los Angeles FC | 0-2 | 5 - 7 points |
| 3/12/22 2:55 PM | 3/12/22 2:55 PM | Seattle Sounders | Los Angeles Galaxy | 3-2 | 5 - 7 points |
| 3/12/22 5:30 PM | 3/12/22 5:30 PM | Houston Dynamo | Vancouver Whitecaps | 2-1 | 5 - 7 points |
| 3/12/22 6:30 PM | 3/12/22 6:30 PM | Orlando City | Cincinnati FC | 1-2 | 5 - 7 points |
| 3/12/22 6:30 PM | 3/12/22 6:30 PM | New England Revolution | Real Salt Lake | 2-3 | 5 - 7 points |
| 3/12/22 6:30 PM | 3/12/22 6:30 PM | D.C. United | Chicago Fire | 0-2 | 5 - 7 points |
| 3/12/22 6:30 PM | 3/12/22 6:30 PM | Philadelphia Union | San Jose Earthquakes | 2-0 | 5 - 7 points |
| 3/12/22 7:30 PM | 3/12/22 7:30 PM | FC Dallas | Nashville SC | 2-0 | 5 - 7 points |
| 3/12/22 8:00 PM | 3/12/22 8:00 PM | Colorado Rapids | Sporting Kansas City | 2-0 | 5 - 7 points |
| 3/12/22 9:00 PM | 3/12/22 9:00 PM | Portland Timbers | Austin FC | 1-0 | 5 - 7 points |
| 3/13/22 3:30 PM | 3/13/22 3:30 PM | Atlanta United FC | Charlotte FC | 2-1 | 5 - 7 points |
| 3/13/22 6:00 PM | 3/13/22 6:00 PM | New York Red Bulls | Minnesota United FC | 0-1 | 5 - 7 points |