Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 8/13/22 5:00 PM | 8/13/22 5:00 PM | New York Red Bulls | Orlando City | 0-1 | 5 - 7 points |
| 8/13/22 6:30 PM | 8/13/22 6:30 PM | New England Revolution | D.C. United | 1-0 | 5 - 7 points |
| 8/13/22 6:30 PM | 8/13/22 6:30 PM | Cincinnati FC | Atlanta United FC | 2-2 | 5 - 7 points |
| 8/13/22 6:30 PM | 8/13/22 6:30 PM | Philadelphia Union | Chicago Fire | 4-1 | 5 - 7 points |
| 8/13/22 6:30 PM | 8/13/22 6:30 PM | Toronto FC | Portland Timbers | 3-1 | 5 - 7 points |
| 8/13/22 7:00 PM | 8/13/22 7:00 PM | Inter Miami CF | New York City FC | 3-2 | 5 - 7 points |
| 8/13/22 8:00 PM | 8/13/22 8:00 PM | Austin FC | Sporting Kansas City | 4-3 | 5 - 7 points |
| 8/13/22 8:00 PM | 8/13/22 8:00 PM | Colorado Rapids | Columbus Crew | 1-1 | 5 - 7 points |
| 8/13/22 8:00 PM | 8/13/22 8:00 PM | Houston Dynamo | CF Montreal | 2-3 | 5 - 7 points |
| 8/13/22 8:00 PM | 8/13/22 8:00 PM | FC Dallas | San Jose Earthquakes | 4-1 | 5 - 7 points |
| 8/13/22 9:00 PM | 8/13/22 9:00 PM | Los Angeles Galaxy | Vancouver Whitecaps | 5-2 | 5 - 7 points |
| 8/13/22 9:30 PM | 8/13/22 9:30 PM | Los Angeles FC | Charlotte FC | 5-0 | 5 - 7 points |
| 8/14/22 8:00 PM | 8/14/22 8:00 PM | Nashville SC | Minnesota United FC | 1-2 | 5 - 7 points |
| 8/14/22 9:00 PM | 8/14/22 9:00 PM | Seattle Sounders | Real Salt Lake | 1-2 | 5 - 7 points |