Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/29/21 6:00 PM | 9/29/21 6:00 PM | Atlanta United FC | Inter Miami CF | 1-0 | 5 - 7 points |
| 9/29/21 6:00 PM | 9/29/21 6:00 PM | Toronto FC | Cincinnati FC | 3-2 | 5 - 7 points |
| 9/29/21 6:30 PM | 9/29/21 6:30 PM | New York Red Bulls | Philadelphia Union | 1-1 | 5 - 7 points |
| 9/29/21 6:30 PM | 9/29/21 6:30 PM | D.C. United | Minnesota United FC | 3-1 | 5 - 7 points |
| 9/29/21 6:30 PM | 9/29/21 6:30 PM | CF Montreal | New England Revolution | 1-4 | 5 - 7 points |
| 9/29/21 7:00 PM | 9/29/21 7:00 PM | Chicago Fire | New York City FC | 2-0 | 5 - 7 points |
| 9/29/21 7:00 PM | 9/29/21 7:00 PM | FC Dallas | Sporting Kansas City | 1-3 | 5 - 7 points |
| 9/29/21 7:30 PM | 9/29/21 7:30 PM | Nashville SC | Orlando City | 2-2 | 5 - 7 points |
| 9/29/21 8:00 PM | 9/29/21 8:00 PM | Colorado Rapids | Austin FC | 3-0 | 5 - 7 points |
| 9/29/21 8:00 PM | 9/29/21 8:00 PM | Houston Dynamo | Vancouver Whitecaps | 0-0 | 5 - 7 points |
| 9/29/21 8:30 PM | 9/29/21 8:30 PM | Real Salt Lake | Los Angeles Galaxy | 2-1 | 5 - 7 points |
| 9/29/21 9:30 PM | 9/29/21 9:30 PM | San Jose Earthquakes | Seattle Sounders | 1-3 | 5 - 7 points |
| 9/29/21 9:30 PM | 9/29/21 9:30 PM | Los Angeles FC | Portland Timbers | 1-2 | 5 - 7 points |