Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 8/6/22 6:00 PM | 8/6/22 6:00 PM | Charlotte FC | Chicago Fire | 2-3 | 5 - 7 points |
| 8/6/22 6:30 PM | 8/6/22 6:30 PM | Columbus Crew | New York City FC | 3-2 | 5 - 7 points |
| 8/6/22 6:30 PM | 8/6/22 6:30 PM | CF Montreal | Inter Miami CF | 2-2 | 5 - 7 points |
| 8/6/22 6:30 PM | 8/6/22 6:30 PM | Cincinnati FC | Philadelphia Union | 3-1 | 5 - 7 points |
| 8/6/22 6:30 PM | 8/6/22 6:30 PM | Orlando City | New England Revolution | 0-3 | 5 - 7 points |
| 8/6/22 6:30 PM | 8/6/22 6:30 PM | D.C. United | New York Red Bulls | 0-0 | 5 - 7 points |
| 8/6/22 7:00 PM | 8/6/22 7:00 PM | Nashville SC | Toronto FC | 3-4 | 5 - 7 points |
| 8/6/22 7:30 PM | 8/6/22 7:30 PM | Sporting Kansas City | Los Angeles Galaxy | 4-2 | 5 - 7 points |
| 8/6/22 8:00 PM | 8/6/22 8:00 PM | Colorado Rapids | Minnesota United FC | 4-3 | 5 - 7 points |
| 8/6/22 8:00 PM | 8/6/22 8:00 PM | Austin FC | San Jose Earthquakes | 3-3 | 5 - 7 points |
| 8/6/22 9:00 PM | 8/6/22 9:00 PM | Real Salt Lake | Los Angeles FC | 1-4 | 5 - 7 points |
| 8/6/22 9:30 PM | 8/6/22 9:30 PM | Portland Timbers | FC Dallas | 1-1 | 5 - 7 points |