Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 7/16/22 6:30 PM | 7/16/22 6:30 PM | Philadelphia Union | New England Revolution | 2-1 | 5 - 7 points |
| 7/16/22 6:30 PM | 7/16/22 6:30 PM | CF Montreal | Toronto FC | 1-0 | 5 - 7 points |
| 7/16/22 7:00 PM | 7/16/22 7:00 PM | Minnesota United FC | D.C. United | 2-0 | 5 - 7 points |
| 7/16/22 7:00 PM | 7/16/22 7:00 PM | Inter Miami CF | Charlotte FC | 3-2 | 5 - 7 points |
| 7/16/22 7:00 PM | 7/16/22 7:00 PM | Chicago Fire | Seattle Sounders | 1-0 | 5 - 7 points |
| 7/16/22 8:00 PM | 7/16/22 8:00 PM | Colorado Rapids | Los Angeles Galaxy | 2-0 | 5 - 7 points |
| 7/16/22 8:00 PM | 7/16/22 8:00 PM | FC Dallas | Austin FC | 1-1 | 5 - 7 points |
| 7/17/22 2:00 PM | 7/17/22 2:00 PM | Atlanta United FC | Orlando City | 1-1 | 5 - 7 points |
| 7/17/22 4:00 PM | 7/17/22 4:00 PM | New York Red Bulls | New York City FC | 0-1 | 5 - 7 points |
| 7/17/22 6:30 PM | 7/17/22 6:30 PM | Columbus Crew | Cincinnati FC | 2-0 | 5 - 7 points |
| 7/17/22 7:30 PM | 7/17/22 7:30 PM | Nashville SC | Los Angeles FC | 1-2 | 5 - 7 points |
| 7/17/22 8:30 PM | 7/17/22 8:30 PM | Real Salt Lake | Sporting Kansas City | 3-0 | 5 - 7 points |
| 7/17/22 8:30 PM | 7/17/22 8:30 PM | San Jose Earthquakes | Houston Dynamo | 1-2 | 5 - 7 points |
| 7/17/22 9:30 PM | 7/17/22 9:30 PM | Portland Timbers | Vancouver Whitecaps | 1-1 | 5 - 7 points |