Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 7/12/22 8:00 PM | 7/12/22 8:00 PM | Austin FC | Houston Dynamo | 3-1 | 5 - 7 points |
| 7/13/22 6:30 PM | 7/13/22 6:30 PM | Atlanta United FC | Real Salt Lake | 2-1 | 5 - 7 points |
| 7/13/22 7:00 PM | 7/13/22 7:00 PM | Chicago Fire | Toronto FC | 2-0 | 5 - 7 points |
| 7/13/22 7:00 PM | 7/13/22 7:00 PM | D.C. United | Columbus Crew | 2-2 | 5 - 7 points |
| 7/13/22 7:00 PM | 7/13/22 7:00 PM | Inter Miami CF | Philadelphia Union | 1-2 | 5 - 7 points |
| 7/13/22 7:00 PM | 7/13/22 7:00 PM | Minnesota United FC | Sporting Kansas City | 1-1 | 5 - 7 points |
| 7/13/22 7:00 PM | 7/13/22 7:00 PM | Cincinnati FC | Vancouver Whitecaps | 2-2 | 5 - 7 points |
| 7/13/22 7:30 PM | 7/13/22 7:30 PM | Nashville SC | Seattle Sounders | 1-0 | 5 - 7 points |
| 7/13/22 8:00 PM | 7/13/22 8:00 PM | FC Dallas | New York City FC | 0-1 | 5 - 7 points |
| 7/13/22 8:00 PM | 7/13/22 8:00 PM | Colorado Rapids | Orlando City | 1-1 | 5 - 7 points |
| 7/13/22 9:00 PM | 7/13/22 9:00 PM | Los Angeles Galaxy | San Jose Earthquakes | 2-3 | 5 - 7 points |