Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 3/5/22 12:30 PM | 3/5/22 12:30 PM | New England Revolution | FC Dallas | 1-0 | 5 - 7 points |
| 3/5/22 1:00 PM | 3/5/22 1:00 PM | Toronto FC | New York Red Bulls | 1-4 | 5 - 7 points |
| 3/5/22 2:30 PM | 3/5/22 2:30 PM | Sporting Kansas City | Houston Dynamo | 1-0 | 5 - 7 points |
| 3/5/22 3:00 PM | 3/5/22 3:00 PM | CF Montreal | Philadelphia Union | 1-2 | 5 - 7 points |
| 3/5/22 4:30 PM | 3/5/22 4:30 PM | San Jose Earthquakes | Columbus Crew | 3-3 | 5 - 7 points |
| 3/5/22 5:00 PM | 3/5/22 5:00 PM | Cincinnati FC | D.C. United | 0-1 | 5 - 7 points |
| 3/5/22 5:00 PM | 3/5/22 5:00 PM | Chicago Fire | Orlando City | 0-0 | 5 - 7 points |
| 3/5/22 5:00 PM | 3/5/22 5:00 PM | Minnesota United FC | Nashville SC | 1-1 | 5 - 7 points |
| 3/5/22 5:00 PM | 3/5/22 5:00 PM | Real Salt Lake | Seattle Sounders | 1-0 | 5 - 7 points |
| 3/5/22 5:00 PM | 3/5/22 5:00 PM | Colorado Rapids | Atlanta United FC | 3-0 | 5 - 7 points |
| 3/5/22 5:00 PM | 3/5/22 5:00 PM | Vancouver Whitecaps | New York City FC | 0-0 | 5 - 7 points |
| 3/5/22 6:30 PM | 3/5/22 6:30 PM | Charlotte FC | Los Angeles Galaxy | 0-1 | 5 - 7 points |
| 3/6/22 3:00 PM | 3/6/22 3:00 PM | Austin FC | Inter Miami CF | 5-1 | 5 - 7 points |
| 3/6/22 9:00 PM | 3/6/22 9:00 PM | Los Angeles FC | Portland Timbers | 1-1 | 5 - 7 points |