Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 4/23/21 6:30 PM | 4/23/21 6:30 PM | Sporting Kansas City | Orlando City | 1-1 | 5 - 7 points |
| 4/24/21 12:00 PM | 4/24/21 12:00 PM | New York City FC | Cincinnati FC | 5-0 | 5 - 7 points |
| 4/24/21 1:00 PM | 4/24/21 1:00 PM | Nashville SC | CF Montreal | 2-2 | 5 - 7 points |
| 4/24/21 2:00 PM | 4/24/21 2:00 PM | Toronto FC | Vancouver Whitecaps | 2-2 | 5 - 7 points |
| 4/24/21 2:30 PM | 4/24/21 2:30 PM | San Jose Earthquakes | FC Dallas | 3-1 | 5 - 7 points |
| 4/24/21 5:00 PM | 4/24/21 5:00 PM | Los Angeles FC | Seattle Sounders | 1-1 | 5 - 7 points |
| 4/24/21 7:00 PM | 4/24/21 7:00 PM | New England Revolution | D.C. United | 1-0 | 5 - 7 points |
| 4/24/21 7:00 PM | 4/24/21 7:00 PM | Philadelphia Union | Inter Miami CF | 1-2 | 5 - 7 points |
| 4/24/21 7:00 PM | 4/24/21 7:00 PM | Atlanta United FC | Chicago Fire | 3-1 | 5 - 7 points |
| 4/24/21 7:00 PM | 4/24/21 7:00 PM | Minnesota United FC | Real Salt Lake | 1-2 | 5 - 7 points |
| 4/24/21 8:00 PM | 4/24/21 8:00 PM | Colorado Rapids | Austin FC | 1-3 | 5 - 7 points |
| 4/24/21 9:30 PM | 4/24/21 9:30 PM | Portland Timbers | Houston Dynamo | 2-1 | 5 - 7 points |
| 4/25/21 4:30 PM | 4/25/21 4:30 PM | Los Angeles Galaxy | New York Red Bulls | 3-2 | 5 - 7 points |