Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 8/7/21 6:30 PM | 8/7/21 6:30 PM | Cincinnati FC | Orlando City | 1-1 | 5 - 7 points |
| 8/7/21 6:30 PM | 8/7/21 6:30 PM | Columbus Crew | Atlanta United FC | 2-3 | 5 - 7 points |
| 8/7/21 7:00 PM | 8/7/21 7:00 PM | Toronto FC | New York City FC | 2-2 | 5 - 7 points |
| 8/7/21 7:00 PM | 8/7/21 7:00 PM | Minnesota United FC | Houston Dynamo | 2-0 | 5 - 7 points |
| 8/7/21 7:30 PM | 8/7/21 7:30 PM | FC Dallas | Austin FC | 2-0 | 5 - 7 points |
| 8/7/21 8:00 PM | 8/7/21 8:00 PM | Colorado Rapids | Sporting Kansas City | 0-0 | 5 - 7 points |
| 8/7/21 9:30 PM | 8/7/21 9:30 PM | Portland Timbers | Real Salt Lake | 3-2 | 5 - 7 points |
| 8/8/21 5:00 PM | 8/8/21 5:00 PM | Chicago Fire | New York Red Bulls | 2-1 | 5 - 7 points |
| 8/8/21 5:00 PM | 8/8/21 5:00 PM | Inter Miami CF | Nashville SC | 2-1 | 5 - 7 points |
| 8/8/21 5:00 PM | 8/8/21 5:00 PM | New England Revolution | Philadelphia Union | 2-1 | 5 - 7 points |
| 8/8/21 6:00 PM | 8/8/21 6:00 PM | San Jose Earthquakes | Los Angeles FC | 2-1 | 5 - 7 points |
| 8/8/21 7:00 PM | 8/8/21 7:00 PM | D.C. United | CF Montreal | 2-1 | 5 - 7 points |
| 8/8/21 7:00 PM | 8/8/21 7:00 PM | Los Angeles Galaxy | Vancouver Whitecaps | 1-1 | 5 - 7 points |