Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 6/18/22 2:00 PM | 6/18/22 2:00 PM | Seattle Sounders | Los Angeles FC | 1-1 | 5 - 7 points |
| 6/18/22 4:00 PM | 6/18/22 4:00 PM | Los Angeles Galaxy | Portland Timbers | 1-1 | 5 - 7 points |
| 6/18/22 6:00 PM | 6/18/22 6:00 PM | New York Red Bulls | Toronto FC | 2-0 | 5 - 7 points |
| 6/18/22 6:30 PM | 6/18/22 6:30 PM | Philadelphia Union | Cincinnati FC | 1-1 | 5 - 7 points |
| 6/18/22 6:30 PM | 6/18/22 6:30 PM | Orlando City | Houston Dynamo | 2-1 | 5 - 7 points |
| 6/18/22 6:30 PM | 6/18/22 6:30 PM | CF Montreal | Austin FC | 0-1 | 5 - 7 points |
| 6/18/22 6:30 PM | 6/18/22 6:30 PM | Columbus Crew | Charlotte FC | 1-1 | 5 - 7 points |
| 6/18/22 7:00 PM | 6/18/22 7:00 PM | Chicago Fire | D.C. United | 1-0 | 5 - 7 points |
| 6/18/22 8:00 PM | 6/18/22 8:00 PM | FC Dallas | Vancouver Whitecaps | 0-2 | 5 - 7 points |
| 6/18/22 8:30 PM | 6/18/22 8:30 PM | Real Salt Lake | San Jose Earthquakes | 2-0 | 5 - 7 points |
| 6/19/22 2:00 PM | 6/19/22 2:00 PM | Atlanta United FC | Inter Miami CF | 2-0 | 5 - 7 points |
| 6/19/22 4:00 PM | 6/19/22 4:00 PM | New York City FC | Colorado Rapids | 1-1 | 5 - 7 points |
| 6/19/22 4:00 PM | 6/19/22 4:00 PM | New England Revolution | Minnesota United FC | 2-1 | 5 - 7 points |
| 6/19/22 5:00 PM | 6/19/22 5:00 PM | Nashville SC | Sporting Kansas City | 1-2 | 5 - 7 points |