Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 7/28/21 9:30 PM | 7/28/21 9:30 PM | Los Angeles FC | Minnesota United FC | 2-2 | 5 - 7 points |
| 7/30/21 6:30 PM | 7/30/21 6:30 PM | New York City FC | Columbus Crew | 4-1 | 5 - 7 points |
| 7/30/21 7:00 PM | 7/30/21 7:00 PM | Orlando City | Atlanta United FC | 3-2 | 5 - 7 points |
| 7/30/21 9:00 PM | 7/30/21 9:00 PM | Los Angeles Galaxy | Portland Timbers | 4-1 | 5 - 7 points |
| 7/31/21 4:00 PM | 7/31/21 4:00 PM | Seattle Sounders | San Jose Earthquakes | 0-1 | 5 - 7 points |
| 7/31/21 5:00 PM | 7/31/21 5:00 PM | New York Red Bulls | New England Revolution | 2-3 | 5 - 7 points |
| 7/31/21 6:30 PM | 7/31/21 6:30 PM | Cincinnati FC | D.C. United | 0-0 | 5 - 7 points |
| 7/31/21 7:00 PM | 7/31/21 7:00 PM | Inter Miami CF | CF Montreal | 2-1 | 5 - 7 points |
| 7/31/21 7:30 PM | 7/31/21 7:30 PM | Sporting Kansas City | FC Dallas | 1-2 | 5 - 7 points |
| 7/31/21 7:30 PM | 7/31/21 7:30 PM | Houston Dynamo | Real Salt Lake | 0-0 | 5 - 7 points |
| 7/31/21 8:00 PM | 7/31/21 8:00 PM | Austin FC | Colorado Rapids | 0-1 | 5 - 7 points |
| 7/31/21 9:00 PM | 7/31/21 9:00 PM | Vancouver Whitecaps | Minnesota United FC | 2-2 | 5 - 7 points |
| 8/1/21 5:00 PM | 8/1/21 5:00 PM | Philadelphia Union | Chicago Fire | 1-1 | 5 - 7 points |
| 8/1/21 6:30 PM | 8/1/21 6:30 PM | Toronto FC | Nashville SC | 1-1 | 5 - 7 points |
| 9/4/21 6:00 PM | 9/4/21 6:00 PM | Vancouver Whitecaps | Austin FC | 2-1 | 5 - 7 points |