Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 5/28/22 5:00 PM | 5/28/22 5:00 PM | Los Angeles FC | San Jose Earthquakes | 3-2 | 5 - 7 points |
| 5/28/22 6:00 PM | 5/28/22 6:00 PM | Atlanta United FC | Columbus Crew | 1-2 | 5 - 7 points |
| 5/28/22 6:00 PM | 5/28/22 6:00 PM | Toronto FC | Chicago Fire | 3-2 | 5 - 7 points |
| 5/28/22 6:00 PM | 5/28/22 6:00 PM | New York Red Bulls | D.C. United | 4-1 | 5 - 7 points |
| 5/28/22 6:30 PM | 5/28/22 6:30 PM | Orlando City | FC Dallas | 1-3 | 5 - 7 points |
| 5/28/22 6:30 PM | 5/28/22 6:30 PM | CF Montreal | Cincinnati FC | 4-3 | 5 - 7 points |
| 5/28/22 6:30 PM | 5/28/22 6:30 PM | New England Revolution | Philadelphia Union | 1-1 | 5 - 7 points |
| 5/28/22 7:00 PM | 5/28/22 7:00 PM | Minnesota United FC | New York City FC | 0-1 | 5 - 7 points |
| 5/28/22 7:00 PM | 5/28/22 7:00 PM | Inter Miami CF | Portland Timbers | 2-1 | 5 - 7 points |
| 5/28/22 8:00 PM | 5/28/22 8:00 PM | Colorado Rapids | Nashville SC | 1-3 | 5 - 7 points |
| 5/28/22 8:00 PM | 5/28/22 8:00 PM | Sporting Kansas City | Vancouver Whitecaps | 0-1 | 5 - 7 points |
| 5/28/22 8:30 PM | 5/28/22 8:30 PM | Real Salt Lake | Houston Dynamo | 3-0 | 5 - 7 points |
| 5/29/22 5:00 PM | 5/29/22 5:00 PM | Los Angeles Galaxy | Austin FC | 4-1 | 5 - 7 points |
| 5/29/22 8:30 PM | 5/29/22 8:30 PM | Seattle Sounders | Charlotte FC | 2-1 | 5 - 7 points |