Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 5/21/22 2:30 PM | 5/21/22 2:30 PM | Columbus Crew | Los Angeles FC | 0-2 | 5 - 7 points |
| 5/21/22 5:00 PM | 5/21/22 5:00 PM | Cincinnati FC | New England Revolution | 2-3 | 5 - 7 points |
| 5/21/22 5:30 PM | 5/21/22 5:30 PM | D.C. United | Toronto FC | 2-2 | 5 - 7 points |
| 5/21/22 6:30 PM | 5/21/22 6:30 PM | Nashville SC | Atlanta United FC | 2-2 | 5 - 7 points |
| 5/22/22 3:00 PM | 5/22/22 3:00 PM | CF Montreal | Real Salt Lake | 1-2 | 5 - 7 points |
| 5/22/22 4:00 PM | 5/22/22 4:00 PM | New York City FC | Chicago Fire | 1-0 | 5 - 7 points |
| 5/22/22 4:00 PM | 5/22/22 4:00 PM | Charlotte FC | Vancouver Whitecaps | 2-1 | 5 - 7 points |
| 5/22/22 5:00 PM | 5/22/22 5:00 PM | Inter Miami CF | New York Red Bulls | 2-0 | 5 - 7 points |
| 5/22/22 6:00 PM | 5/22/22 6:00 PM | FC Dallas | Minnesota United FC | 1-2 | 5 - 7 points |
| 5/22/22 6:30 PM | 5/22/22 6:30 PM | San Jose Earthquakes | Sporting Kansas City | 1-1 | 5 - 7 points |
| 5/22/22 7:00 PM | 5/22/22 7:00 PM | Los Angeles Galaxy | Houston Dynamo | 0-3 | 5 - 7 points |
| 5/22/22 7:00 PM | 5/22/22 7:00 PM | Colorado Rapids | Seattle Sounders | 1-0 | 5 - 7 points |
| 5/22/22 7:00 PM | 5/22/22 7:00 PM | Austin FC | Orlando City | 2-2 | 5 - 7 points |
| 5/22/22 9:00 PM | 5/22/22 9:00 PM | Portland Timbers | Philadelphia Union | 0-2 | 5 - 7 points |