Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 5/4/22 6:30 PM | 5/4/22 6:30 PM | Cincinnati FC | Toronto FC | 2-0 | 5 - 7 points |
| 5/18/22 6:30 PM | 5/18/22 6:30 PM | D.C. United | New York City FC | 0-2 | 5 - 7 points |
| 5/18/22 6:30 PM | 5/18/22 6:30 PM | Philadelphia Union | Inter Miami CF | 0-0 | 5 - 7 points |
| 5/18/22 6:30 PM | 5/18/22 6:30 PM | New York Red Bulls | Chicago Fire | 3-3 | 5 - 7 points |
| 5/18/22 7:00 PM | 5/18/22 7:00 PM | Minnesota United FC | Los Angeles Galaxy | 1-1 | 5 - 7 points |
| 5/18/22 7:30 PM | 5/18/22 7:30 PM | Houston Dynamo | Seattle Sounders | 0-1 | 5 - 7 points |
| 5/18/22 7:30 PM | 5/18/22 7:30 PM | Nashville SC | CF Montreal | 2-1 | 5 - 7 points |
| 5/18/22 7:30 PM | 5/18/22 7:30 PM | Sporting Kansas City | Colorado Rapids | 2-1 | 5 - 7 points |
| 5/18/22 9:00 PM | 5/18/22 9:00 PM | Vancouver Whitecaps | FC Dallas | 2-1 | 5 - 7 points |
| 5/18/22 9:30 PM | 5/18/22 9:30 PM | Los Angeles FC | Austin FC | 1-2 | 5 - 7 points |
| 5/18/22 9:30 PM | 5/18/22 9:30 PM | San Jose Earthquakes | Portland Timbers | 3-2 | 5 - 7 points |